Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Aging &amp; Longevity

Model: C57BL/6N male mice 
Dosage: AIN-93 M diet with 0.025% (15 mg/kg per day) niclosamide for the Old + NL group or 0.050% (30 mg/kg per day) niclosamide for the Old + NH group, starting at 12 months of age to 21 months of age

Drug Approved Against Tapeworms May Counteract Aging, Suggests New Study

New research suggests niclosamide, approved for human use against tapeworms, alleviates frailty and suppresses the protein complex mTOR, which regulates cell growth, in aged mice.

(The drug niclosamide | Hospital Pharmacy Europe)

Niclosamide, an agent approved for human use against tapeworms, alleviates age-related frailty, suppresses mTOR, and activates autophagy in old mice.

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Aging interventions that include NAD+ precursors have evolved, adding components targeting various hallmarks of aging, from inflammation to cell waste elimination.

Some aging intervention products with NAD+ precursors, like Seragon’s Restorin, have evolved to include additional components targeting multiple hallmarks of aging.

Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Might Extend Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Search Result: Life Extension

Longevity Prescription

Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Common Diabetes Medication Might Extend Life, Suggests New Study

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study