Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Aging &amp; Longevity

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

David Attenborough Turns 100: 5 Longevity Habits of the Renowned British Broadcaster

David Attenborough’s longevity secrets encompass simple practices, such as walking, eating plant foods, spending time in nature, and maintaining social connections.

David Attenborough’s longevity secrets include not eating much meat, having a sense of purpose, eating small meals, spending time in nature, and maintaining social connections.

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

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10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

Top Evidence-Based Interventions to Lower Biological Age

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

David Attenborough Turns 100: 5 Longevity Habits of the Renowned British Broadcaster

Rapamycin and Exercise: New Study Finds Potential Performance Decline