Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Cardiovascular

Model: 24-month-old male C57BL/6J mice 
Dosage: 1% w/v of betaine for three weeks

The naturally occurring compound betaine is elevated in healthy adults after long-term exercise and mitigates signs of aging in mice. 

Immunity

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

According to French scientists, no organ system appears as vulnerable to aging as the cardiovascular system, and anti-aging therapeutics may help mitigate the effects of cardiovascular disease.

(The principal investigator behind the review, aging researcher Guido Kroemer | Olympiad in Cardiovascular Medicine)

Anti-aging therapeutics may prevent and slow age-related cardiovascular dysfunction.

Participants: Healthy older adults 
Dosage: 1 mg/day of rapamycin for 8 weeks

Older adults taking low-dose rapamycin exhibit a reduction in senescent cells — cells that contribute to age-related diseases and a shorter lifespan. 

Associate professor at Oxford University and corresponding author on the study, Lynne S Cox, MA, PhD (image: researchgate.com).

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults. 

An ultrasound of the carotid artery with arrows pointing to plaques (image: avicennacardiology.com). 

Search Result: LDL

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

“Exercise in a Pill”? Betaine Supplement Shows Anti-Aging Benefits

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

New Oxford Study: Powerful Longevity Drug Rapamycin Targets Cell Senescence

New Study Reveals: High-Dose Supplement Shrinks Arterial Plaque by 36%