Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Brain &amp; Neurons

Andrew Huberman’s Updated Supplement Stack for 2026

Stanford neuroscientist Andrew Huberman’s updated supplement list includes the NAD+ precursor NMN, along with other compounds for sleep and cognitive performance.

Dr. Andrew Huberman’s new supplement stack for 2026 includes NMN, along with supplements supporting sleep, testosterone synthesis, and cognitive function.

Aging &amp; Longevity

The Anti-Aging Debate Everyone’s Talking About: Inside Bryan Johnson’s Jubilee Showdown

Bryan Johnson debates 20 skeptics on anti-aging in Jubilee’s viral episode and challenges assumptions about lifespan, science, and the future of human health.


Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Search Result: Insulin Sensitivity

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

Andrew Huberman’s Updated Supplement Stack for 2026

The Anti-Aging Debate Everyone’s Talking About: Inside Bryan Johnson’s Jubilee Showdown

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan