Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Brain &amp; Neurons

Model: C57BL/6 mice and Zpmste24-deficient progeria mice
Dosage: .03% w/w of canagliflozin mixed into diets from day 3 to 20 weeks

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Japanese scientists uncover that a diabetes drug called canagliflozin removes senescent cells and moderately extends lifespan in a mouse model of premature aging.

(A laboratory mouse alongside the molecular structure of canagliflozin | NAD.com)

The diabetes medication canagliflozin clears senescent cells and extends lifespan in a mouse model of premature aging called progeria.

Aging &amp; Longevity

According to a new scientific review, sarcopenia — age-related muscle loss — can potentially be mitigated by replenishing NAD+. 


Skin &amp; Muscle

Scientists maintain the function of fat-derived stem cells by boosting NAD+ with nicotinamide riboside (NR), which could combat age-related liver and muscle ailments.



A woman next to a nicotinamide riboside (NR) molecule. 

Model: Adults over age 40
Dosage: An average of 25 mg of dietary niacin per day and up to 238 mg per day

New Study Links NAD⁺ Precursor Niacin with Muscle Strength and Insulin Sensitivity

Researchers show a link between higher dietary niacin and improved muscle strength, lower body fat, and enhanced insulin sensitivity in adults over age 40.

(A muscular man in his 40s alongside a niacin molecule)

Discover groundbreaking findings from the latest study on niacin, a precursor to NAD, revealing its remarkable benefits for boosting muscle strength and improving insulin sensitivity in adults over 40. Explore the full story at NAD.com.

Search Result: Homeostasis

How Does the Immune System Affect the Brain? Scientists Reveal How to Slow Brain Aging

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Can Boosting NAD+ Prevent Muscle Loss with Age?

When More Fat is Good: Study Shows NAD⁺ Precursor NR Rejuvenates Fat Stem Cells

New Study Links NAD⁺ Precursor Niacin with Muscle Strength and Insulin Sensitivity