Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Cardiovascular

Scientists say combining exercise with NAD+ (nicotinamide adenine dinucleotide) precursors may synergistically improve physical performance.  

We can’t get NAD+ directly from food, but some foods provide the materials necessary for our cells to make NAD+.  

An example of an NAD+ boosting meal, consisting of chicken breast and green lentils. 

Model: C57BL/6 mice and Zpmste24-deficient progeria mice
Dosage: .03% w/w of canagliflozin mixed into diets from day 3 to 20 weeks

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Japanese scientists uncover that a diabetes drug called canagliflozin removes senescent cells and moderately extends lifespan in a mouse model of premature aging.

(A laboratory mouse alongside the molecular structure of canagliflozin | NAD.com)

The diabetes medication canagliflozin clears senescent cells and extends lifespan in a mouse model of premature aging called progeria.

Aging &amp; Longevity

Six Intriguing Ideas from David Sinclair’s Book, Lifespan

In his book, Harvard’s Dr. David Sinclair presents concepts such as the Information Theory of Aging — how modifications to our DNA may cause aging.

(Lifespan: Why We Age — and Why We Don’t Have To | booko.com.au)

Harvard’s Dr. David Sinclair presents six thrilling ideas in his book Lifespan, which include his Information Theory of Aging — changes to chemical modifications on DNA that underlie all aging processes.

Search Result: High-fat Diet

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

Unlocking Youth: The Combined Power of NAD+ and Exercise

What Foods Are High in NAD+?

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Six Intriguing Ideas from David Sinclair’s Book, Lifespan: Why We Age — and Why We Don’t Have To