Model: Young (2- to 4-month-old) and aged (9- to 10-month-old) C57Bl/6JR mice, APP/PS1 mice, and 5xFAD mice 
Dosage: 0.2 mg/mL of doxycycline in drinking water starting at least 7 days before surgery and ceased 2 days before the partial cellular reprogramming window for engram tagging, after which it was immediately reintroduced

Gene Therapy Restores Cognitive Function in Aging and Alzheimer’s Disease

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

(The study’s principal investigator, Professor Johannes Gräff | 24 Heures)

A partial cellular reprogramming gene therapy targeting memory trace cells restores facets of learning and memory in aged mice and those modeling Alzheimer’s disease.

Brain &amp; Neurons

Approved Human Study Sets Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

In a major proving ground test for the longevity field, the FDA has given its approval for a human trial for a gene therapy attempting a near-total rejuvenating reset of cells.

(David Sinclair, Michael Ringel, Sharon Rosenzweig-Lipson, and Jerry McLaughlin of Life Biosciences | Longevity.technology)

The FDA has greenlighted Life Biosciences’ first human trial testing whether their gene therapy can confer a near-total rejuvenating reset of cells.

Clinical Trials

Elon Musk Says Figuring Out How to Reverse Aging ‘Highly Likely’

The business magnate and SpaceX CEO, Elon Musk, now believes that death is a kind of engineering bug that determined aging scientists can eventually fix.

The high-profile American entrepreneur, Elon Musk, now says figuring out human lifespan extension is highly likely.

Aging &amp; Longevity

Model: 24-month-old male C57BL/6J mice 
Dosage: 1% w/v of betaine for three weeks

The naturally occurring compound betaine is elevated in healthy adults after long-term exercise and mitigates signs of aging in mice. 

Immunity

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.


Search Result: David Sinclair

Gene Therapy Targeting Memory-Encoding Neurons Restores Cognitive Function in Aging and Alzheimer’s Disease

FDA Greenlights Life Biosciences’ Human Study, Setting Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

Elon Musk Says Figuring Out How to Reverse Aging ‘Highly Likely’

“Exercise in a Pill”? Betaine Supplement Shows Anti-Aging Benefits

Top Aging Expert & Peter Attia Discuss NAD+ Precursors: Taking NMN and NR Together