Peter Fedichev’s Physics-Based Approach to Aging: A New Longevity Framework

Peter Fedichev describes aging as a three-variable system of stress (from physical, psychological, or molecular stressors), noise (small random biological fluctuations), and damage (cumulative wear-and-tear).

Peter Fedichev has proposed a physics-based framework for aging, encompassing stress, noise (small random biological fluctuations), and damage (cumulative wear-and-tear).

Aging &amp; Longevity

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

What Is Mosaic Aging? How Organs Age at Different Rates

A new framework proposes that the patchwork nature of aging, where different organs deteriorate at different speeds, may hold the key to understanding the ultimate cause of death.

(University of Glasgow logo | Scotland.org)

A new framework proposes that aging occurs unevenly in cells, tissues, and organs, and that targeting the fastest-aging tissues may extend lifespan.

Aging Guru Bryan Johnson’s Supplement List for 2026

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

(Bryan Johnson, who utilizes a continuously updated protocol to slow aging and optimize his body | Netflix)

Changes to Bryan Johnson’s updated 2026 supplement stack include taking NMN or NR six days a week instead of seven and removing rapamycin.

Model: Middle-aged cynomolgus monkeys
Dosage: 30 mg/kg/day of vitamin C, orally administered for 40 months

Vitamin C Alleviates Aging in Monkeys

Vitamin C improves brain volume and connectivity, reduces biological age, enhances metabolic health, and alleviates underlying aging drivers, such as cellular senescence, in older monkeys. 

Search Result: DNA Damage

Peter Fedichev’s Physics-Based Approach to Aging: A New Longevity Framework

Rapamycin and Exercise: New Study Finds Potential Performance Decline

What Is Mosaic Aging? How Organs Age at Different Rates

Aging Guru Bryan Johnson’s Supplement List for 2026

Vitamin C Alleviates Aging in Monkeys, New Study Shows