NAD+ Supercharges Immune System Recovery in Older Mice

Researchers from the University of California, Berkeley, found that young mice need NAD+ breakdown, while old mice need NAD+ boosting.

Immunity

The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s. 


Principal investigator Michal Shwartz, PhD (Image: Jonathan Bloom).

Brain &amp; Neurons

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

Aging interventions that include NAD+ precursors have evolved, adding components targeting various hallmarks of aging, from inflammation to cell waste elimination.

Some aging intervention products with NAD+ precursors, like Seragon’s Restorin, have evolved to include additional components targeting multiple hallmarks of aging.

Aging &amp; Longevity

<p>Model: Humans between the ages of 21 and 72</p>
<p>Dosage: Oral dosage of 500 mg of nicotinamide, 600 mg of alpha lipoic acid, 10 mg of zinc, 20 mg of vitamin C, and 2,110 mg of a botanical blend containing green tea extract, rutin, parsley leaf extract, and black pepper fruit daily for 28 days</p>


A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

British researchers designed a nutraceutical to maximize nicotinamide adenine dinucleotide (NAD+) levels that significantly lowers biological age.

British researchers used a nutraceutical targeting multiple NAD+ biosynthesis- and breakdown-related enzymes to increase NAD+, lower inflammation, and increase sirtuins.

While human studies are needed to determine its true effect on aging, apigenin may improve sleep in anxious individuals.

Apigenin supplement improves sleep of anxious and promotes increases in NAD+ levels. 

Search Result: CD38

NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice

Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows

Seragon’s RESTORIN and the Evolution of Aging Interventions Containing NAD+ Precursors

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

Is Apigenin Safe? And How it Improves Sleep and Aging