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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

<p><strong data-start="26" data-end="36">Model:</strong> Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.</p>
<p><strong data-start="222" data-end="233">Dosage:</strong> Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of <em data-start="339" data-end="363">Kluyveromyces fragilis</em> yeast extract, 350 mg of <em data-start="393" data-end="419">Saccharomyces cerevisiae</em> yeast extract, or a placebo.</p>


Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

Russia’s $27 Billion Bet on Beating Aging—Hype or Hope?

With an ambitious goal of conquering aging, Russia is investing $26 to $28 billion in a national health initiative.

(Russian leader, Vladimir Putin | RBC-Ukraine)

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

<p>Model: 8-month-old female Swiss mice</p>
<p>Dosage: 200 µL of aged-derived fecal suspension administered orally three days per week for two weeks</p>


New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Spanish scientists unveil data showing that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

(A depiction of the intestines filled with gut microbes | Northwestern Medicine)

Spanish scientists show that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

Search Result: Biological Age

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Russia’s $27 Billion Bet on Beating Aging—Hype or Hope?

Top Evidence-Based Interventions to Lower Biological Age

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan