Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Brain &amp; Neurons

Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Aging &amp; Longevity

Participants: Werner syndrome patients 
Dosage: 1 gram of NR per day for 26 weeks

The NAD+ (nicotinamide adenine dinucleotide) booster NR (nicotinamide riboside) improves cardiovascular health in Werner syndrome patients. 

A child with Werner syndrome (image: britannica.com)

German researchers discover rare genetic mutations related to the mTOR pathway in the DNA of long-lived individuals. 

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Search Result: Autophagy

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

NAD+ Precursor NR Improves Heart Health in People with Accelerated Aging, New Study Shows

Longevity Secrets in Your Genome: Hidden mTOR Variants Identified

Longevity Prescription