How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

Aging &amp; Longevity

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

NAD+ (nicotinamide adenine dinucleotide) may contribute to healthy cellular aging by enhancing biological energy flow, according to the newly formulated energy resistance principle.


In remembrance of Jane Goodall: The science-backed lifestyle factors that likely contributed to her long life and sound mind.  

Jane Goodall, PhD (image: thenationalnews.com).

Search Result: Antioxidants

How to Boost Mitochondrial Density and Quality for Longevity

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NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

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Remembering Jane Goodall: The Simple Habits That Kept Her Mind Sharp for 91 Years