Model: Ten-month-old male EFAD mice 
Dosage: 14.4 ppm of alfatradiol in diet for five months

USC Study: Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer's

The drug alfatradiol, also known as 17ɑ-estradiol, reduces cognitive errors on a test of memory and lowers neuronal plaques in mice genetically predisposed to Alzheimer’s disease.

(The University of Southern California | College Matchpoint)

Researchers unveil data suggesting the drug alfatradiol improves signs of frailty, reduces cognitive errors, and reduces neuronal plaques in mice with a genetic predisposition to Alzheimer’s disease.

Brain &amp; Neurons

Model: UM-HET3 mice and 5XFAD mice 
Dosage: UM=HET3 mice received 180 mg/kg canagliflozin in chow starting at seven months of age, and FXFAD mice received 180 mg/kg canagliflozin in chow beginning at three months of age

New Study: Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression

The diabetes drug canagliflozin improves learning and memory in middle-aged male mice and reduces brain plaques in Alzheimer’s model mice.

The FDA-approved diabetes medication canagliflozin improves cognition in a mouse model of Alzheimer’s disease in males only.

Supplementing with 20 grams of creatine improves the cognition of individuals with Alzheimer’s disease. 

The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s. 


Principal investigator Michal Shwartz, PhD (Image: Jonathan Bloom).

The Dementia Surge: New Study Projects Cases to Double by 2060

Researchers project dementia cases in the U.S. to double by 2060, revealing higher incidence in women, Black adults, and APOE ε4 carriers

Search Result: Amyloid

USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s

Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study

Creatine Supplement Improves Memory in People with Alzheimer’s: New Pilot Study

Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows

The Dementia Surge: New Study Projects Cases to Double by 2060