In a randomized clinical trial, active and healthy older adults who took a multi-supplement and omega-3 fatty acids saw a reduction in age-related chronic inflammation after 12 weeks. 

Immunity

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

A combined treatment of NMN with 78c (a small molecule that inhibits an NAD+-degrading enzyme) enhances the effects of the anti-cancer CAR-T cell therapy in aged mice and human cells.

(A CAR-T cell [red] attacking a cancer cell [blue] | Crown Bioscience Blog)

Cancer

While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice. 


The study was funded by the National Institute on Aging, one of the National Institutes of Health (NIH). 

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults. 

An ultrasound of the carotid artery with arrows pointing to plaques (image: avicennacardiology.com). 

Cardiovascular

<p>Model: Ten-month-old male EFAD mice<br />
Dosage: 14.4 ppm of alfatradiol in diet for five months</p>


USC Study: Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer's

The drug alfatradiol, also known as 17ɑ-estradiol, reduces cognitive errors on a test of memory and lowers neuronal plaques in mice genetically predisposed to Alzheimer’s disease.

(The University of Southern California | College Matchpoint)

Researchers unveil data suggesting the drug alfatradiol improves signs of frailty, reduces cognitive errors, and reduces neuronal plaques in mice with a genetic predisposition to Alzheimer’s disease.

Search Result: Aging Population

Clinical Omega-3 Longevity Stack: A New Clue in the Fight Against Age-Related Chronic Inflammation

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

Anti-Aging NAD+ Precursor Supplement May Promote Anxiety, New Study Shows

New Study Reveals: High-Dose Supplement Shrinks Arterial Plaque by 36%

USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s