Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Model: SAMP8 mice 
Dosage: ~25 mg/kg/day of PQQ or PQI administered in food

Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


Aging &amp; Longevity

Examining Evidence for the Cognition-Enhancing Potential of the Antioxidant Astaxanthin

The antioxidant astaxanthin significantly extends male mouse lifespan, and human research suggests it may help prevent age-related cognitive decline.

(An image of the red-orange pigment astaxanthin | Gruppo Farmalmpresa)

The potent antioxidant astaxanthin may have pro-longevity effects, and human trial data suggests it improves cognitive function in older adults.

Model: 699 European adults with an average age of 63.11 years

Longest Aging Clock Study to Date Shows Robust Improvement in Mortality Risk Prediction

A new study provides evidence that using aging clocks based on molecular tagging patterns on DNA (epigenetic aging clocks) to take multiple age readings across time outperforms taking single measurements in predicting mortality.

(The study’s principal investigator, Luigi Ferrucci | LinkedIn)

An Institute for Research on Aging study provides evidence that using epigenetic aging tests at multiple time points predicts mortality better than a single measurement.

Epigenetics

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Human trials report that GlyNAC and exercise regimens improve dysfunction of the cell’s powerhouses (mitochondria), inflammation, muscle strength, and cognition.

(Some GlyNAC tablets above the chemical structure of GlyNAC | Vitamin Retailer)

GlyNAC supplementation and exercise alleviate mitochondrial dysfunction, lower inflammation, increase muscle strength, and bolster cognition.

Search Result: Aged Adults

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

Examining Evidence for the Cognition-Enhancing Potential of the Antioxidant Astaxanthin

Longest Aging Clock Study to Date Shows Robust Improvement in Mortality Risk Prediction

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence