Participants: Healthy middle-aged adults 
Dosage: 1200 mg/day of NR for 4 weeks

NR (nicotinamide riboside) raises blood NAD+ (nicotinamide adenine dinucleotide) levels more than NMN (nicotinamide mononucleotide) in healthy adults. 

Some of the researchers on the study, Dr. Christian Dölle (left) and Dr. Charalampos Tzoulis (middle) from the University of Bergen in Norway (image: uib.no). 

Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

How to Support Muscle Function with Age: Top Evidence-Based Supplements

Data suggest certain supplements, such as L-carnitine, vitamin D, and essential minerals, support muscle function and physical performance in adults of advanced age.

Researchers from University College London review data supporting that supplements, like vitamin D, L-carnitine, and essential minerals, support muscle function during aging.

Skin &amp; Muscle

Model: Male C57BL/6 mice given continuous alcohol for 4 weeks 
Dosage: 350 mg/kg/day of nicotinamide riboside chloride for 2 weeks

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide riboside (NR) counteracts neuronal damage caused by alcohol consumption in mice. 

Search Result: ATP

NR Raises NAD+ Over 2-Fold More than NMN: New Study Comparing NAD+ Precursors

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan

How to Support Muscle Function with Age: Top Evidence-Based Supplements

NAD+ Supplement Counters Alcohol-Induced Brain Aging, According to New Study