Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Aging &amp; Longevity

Model: Female ICR (Institute of Cancer Research) mice
Dosage: ~240 mg/day of pterostilbene within food

Pterostilbene Promotes Fertility in Aged Females

The plant-based antioxidant, pterostilbene, improves egg quality in aged mice, as measured by an increase in live offspring. 

Blueberries are among the richest natural sources of pterostilbene. 

Model: Middle-aged cynomolgus monkeys
Dosage: 30 mg/kg/day of vitamin C, orally administered for 40 months

Vitamin C Alleviates Aging in Monkeys

Vitamin C improves brain volume and connectivity, reduces biological age, enhances metabolic health, and alleviates underlying aging drivers, such as cellular senescence, in older monkeys. 

Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Researchers at Case Western Reserve University have shown that late-stage neurodegeneration may be biologically reversible, at least in the right conditions, in mice.

(Case Western Reserve University | Cleveland 19)

Brain &amp; Neurons

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

Search Result: AGEs

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

Pterostilbene and Fertility: New Study on Restoring Reproductive Aging

Vitamin C Alleviates Aging in Monkeys, New Study Shows

Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain