Approved Human Study Sets Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

In a major proving ground test for the longevity field, the FDA has given its approval for a human trial for a gene therapy attempting a near-total rejuvenating reset of cells.

(David Sinclair, Michael Ringel, Sharon Rosenzweig-Lipson, and Jerry McLaughlin of Life Biosciences | Longevity.technology)

The FDA has greenlighted Life Biosciences’ first human trial testing whether their gene therapy can confer a near-total rejuvenating reset of cells.

Clinical Trials

Based on current scientific evidence, Dutch researchers have ranked existing anti-aging interventions based on how likely they are to protect against DNA damage and aging. 


On the far right, one of the researchers, Dr. Jan H.J. Hoeijmakers (image: amazinggerasmusmc.nl). 

DNA Repair

<p>Model: Male C57BL/6J mice </p>
<p>Dosage: 150 mg/kg/day of diallyl sulforated compounds in food </p>


Diallyl sulfonated compounds (DAS), found in garlic, extend the lifespan of mice while counteracting signs of aging, such as grip weakness and memory loss. 

Dr. Vivian Capilla-González, one of the researchers on the study (image: cde.ual.es).

Aging &amp; Longevity

How to Boost Mitochondrial Tissue Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

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FDA Greenlights Life Biosciences’ Human Study, Setting Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

NAD+ Ranked #2 Most Powerful Way to Reverse DNA Damage & Aging

Garlic Compound Extends Life, Builds Strength, and Boosts Memory, New Study Shows

How to Boost Mitochondrial Tissue Density and Quality for Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging