While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice. 


The study was funded by the National Institute on Aging, one of the National Institutes of Health (NIH). 

Immunity

Model: Cybrids composed of Rho0 cells with human platelet mitochondrial DNA from participants between 7 days old and 99 years old 
Dosage: 5 mM of n-Acetyl-L-Cysteine and 3 mM of nicotinamide riboside, with medium changed every three days until the cell population reached between 1 and 10 million

New Study: Combining NR with NAC May Slow Telomere Shortening

New research suggests that nicotinamide riboside (NR) combined with N-acetyl cysteine (NAC) prevents telomere shortening linked to genetic sequences within the cell’s powerhouse (mitochondria) in human cells.

(Telomeres [highlighted in gold] at the ends of a chromosome | NAD.com)

A new study suggests the NAD+ precursor NR combined with the antioxidant NAC may counteract telomere shortening, a hallmark of aging.

Aging &amp; Longevity

A molecule found in the plasma of exercised mice reverses the brain aging of sedentary mice. 

(Image: UCSF.edu) Senior author Saul Villeda, PhD. 

Model: 18-month-old CD45.2 mice
Dosage: 4 ug Netrin-1 via injection; 5 injections total; once every 35 days

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Infusing blood with a molecule critical for development, Netrin-1, improves the bone marrow niche in older people and restores the function of older blood stem cells, which has the potential to help people live longer.


Basic Research

Harvard and MIT Discover New Anti-Aging Drugs Using AI

By training AI to screen over 800,000 molecules, MIT and Harvard University researchers identified thousands of candidate compounds that can improve aging.


Search Result: platelets

Anti-Aging NAD+ Precursor Supplement May Promote Anxiety, New Study Shows

New Study: Combining NR with NAC May Slow Telomere Shortening

Scientists Identify a Molecule that Mimics the Anti-Aging Effects of Exercise on the Brain

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Harvard and MIT Discover New Anti-Aging Drugs Using AI