Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice. 


The study was funded by the National Institute on Aging, one of the National Institutes of Health (NIH). 

Immunity

Model: Cybrids composed of Rho0 cells with human platelet mitochondrial DNA from participants between 7 days old and 99 years old 
Dosage: 5 mM of n-Acetyl-L-Cysteine and 3 mM of nicotinamide riboside, with medium changed every three days until the cell population reached between 1 and 10 million

New Study: Combining NR with NAC May Slow Telomere Shortening

New research suggests that nicotinamide riboside (NR) combined with N-acetyl cysteine (NAC) prevents telomere shortening linked to genetic sequences within the cell’s powerhouse (mitochondria) in human cells.

(Telomeres [highlighted in gold] at the ends of a chromosome | NAD.com)

A new study suggests the NAD+ precursor NR combined with the antioxidant NAC may counteract telomere shortening, a hallmark of aging.

Aging &amp; Longevity

A molecule found in the plasma of exercised mice reverses the brain aging of sedentary mice. 

(Image: UCSF.edu) Senior author Saul Villeda, PhD. 

Model: 18-month-old CD45.2 mice
Dosage: 4 ug Netrin-1 via injection; 5 injections total; once every 35 days

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Infusing blood with a molecule critical for development, Netrin-1, improves the bone marrow niche in older people and restores the function of older blood stem cells, which has the potential to help people live longer.


Search Result: platelets

Rapamycin and Exercise: New Study Finds Potential Performance Decline

Anti-Aging NAD+ Precursor Supplement Prevents Immune Decline, New Study Shows

New Study: Combining NR with NAC May Slow Telomere Shortening

Scientists Identify a Molecule that Mimics the Anti-Aging Effects of Exercise on the Brain

Researchers Rejuvenate Aged Mouse Blood Stem Cells