Model: Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.
Dosage: Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of Kluyveromyces fragilis yeast extract, 350 mg of Saccharomyces cerevisiae yeast extract, or a placebo.

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

Supplementing with ergothioneine — a compound found in lion’s mane mushrooms — enhances the verbal memory of elderly individuals. 

(Image: marthastewart.com) Lion’s mane mushrooms.

Participants: 50- to 80-year-old individuals 
Dosage: A drink containing 1 × 1010 colony-forming units of Bifidobacterium animalis subsp. lactis GCL2505 and 2.0 g of inulin per 100 g

Middle-aged and older adults showed improvements in cognitive ability after drinking a mixture of probiotics — beneficial bacteria — and fiber. 


Search Result: mild cognitive impairment (MCI)

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Common Joint Health Supplement May Progress Dementia, New Study Finds

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

Ergothioneine Longevity Supplement Enhances Verbal Memory

Probiotic and Fiber Drink Deters Dementia in New Japanese Study