Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Brain &amp; Neurons

Model: Young (2- to 4-month-old) and aged (9- to 10-month-old) C57Bl/6JR mice, APP/PS1 mice, and 5xFAD mice 
Dosage: 0.2 mg/mL of doxycycline in drinking water starting at least 7 days before surgery and ceased 2 days before the partial cellular reprogramming window for engram tagging, after which it was immediately reintroduced

Gene Therapy Restores Cognitive Function in Aging and Alzheimer’s Disease

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

(The study’s principal investigator, Professor Johannes Gräff | 24 Heures)

A partial cellular reprogramming gene therapy targeting memory trace cells restores facets of learning and memory in aged mice and those modeling Alzheimer’s disease.

Participants: Healthy middle-aged adults 
Dosage: 1200 mg/day of NR for 4 weeks

NR (nicotinamide riboside) raises blood NAD+ (nicotinamide adenine dinucleotide) levels more than NMN (nicotinamide mononucleotide) in healthy adults. 

Some of the researchers on the study, Dr. Christian Dölle (left) and Dr. Charalampos Tzoulis (middle) from the University of Bergen in Norway (image: uib.no). 

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Search Result: middle age

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

Gene Therapy Targeting Memory-Encoding Neurons Restores Cognitive Function in Aging and Alzheimer’s Disease

NR Raises NAD+ Over 2-Fold More than NMN: New Study Comparing NAD+ Precursors

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research