Model: C57BL/6J mice 
Dosage: Eating only within an 8-hour window and fasting for 16 hours (~20% caloric deficit may be required)

Restricting food intake for 16 hours a day improves the health of female mice and moderately prolongs the life of male mice. 

The principal investigators of the study (from left to right): Dr. Carla Green, Dr. Victoria Acosta-Rodriguez, and Dr. Joseph Takahashi (image: dallasnews.com). 

Aging &amp; Longevity

Model: SAMP8 mice 
Dosage: ~25 mg/kg/day of PQQ or PQI administered in food

Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Model: 14- to 15-month-old male C57BL/6J mice
Dosage: 50 mg injection of 3′-deoxyadenosine (cordycepin) because it was shown not to be absorbed if administered orally

Mushroom Compound Prolongs Lifespan If Taken At Correct Time

In mice, cordycepin—a molecule found in cordyceps mushrooms—prolongs lifespan and improves memory, strength, cardiac function, hormone levels, and metabolism. 


Cordyceps mushrooms (image: antioxi-supplements.com). 

Participants: Healthy overweight adults between the ages of 45 and 55 
Dosage: 3 grams/day of ginseng for 28 days

Ginseng Boosts NAD+ and Telomeres: New Study in Middle-Aged Adults

Ginseng supplementation boosts NAD+ (nicotinamide adenine dinucleotide) and lengthens telomeres in middle-aged adults, suggesting an amelioration of aging. 


Panax ginseng Meyer (image: farmaimpresa.com).

Search Result: middle age

16-Hour Intermittent Fasting Improves Health and Longevity, New Study Confirms

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

Rapamycin and Exercise: New Study Finds Potential Performance Decline

Cordyceps Mushroom Molecule Prolongs Lifespan If Taken At Correct Time of Day, New Study Shows

Ginseng Boosts NAD+ and Telomeres: New Study in Middle-Aged Adults