Pioneering expert in NAD+ metabolism, Shin-Ichiro Imai, MD, PhD, explains the critical role of NAD+ in preventing chronic kidney disease, the ninth leading cause of death worldwide. 


Dr. Shin-Ichiro Imai (image: mspremium.com)

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.  


Principal investigator Nora Kory, PhD, from Harvard University (image: harvard.edu). 

Multi-Nation Expert Panel Agrees On Biomarkers of Aging

For the first time, a multi-nation panel of aging experts reached a consensus to designate markers of aging, which could make aging intervention testing easier.

(An aged individual holding pills and supplements meant to work against aging | UCLA)

Aging &amp; Longevity

A molecule known as miR-302b prolongs the life of mice by “waking up” senescent cells — “sleeping” cells that contribute to life-shortening chronic diseases. 

Depiction of microRNA molecules (Image: Artur Plawgo/iStock Photo/MIT.edu). 

<p>Model: C57BL/6N mice<br />
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days</p>


New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Search Result: kidney damage

Expert Explains Role of NAD+ in Preventing Age-Related Kidney Disease

Harvard Scientists Unravel the Role of NAD+ Transporter in Mitigating Age-Related Diabetes

Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics

New Age-Reversal Therapy Prolongs Life by Targeting Senescent Cells

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study