Model: Middle-aged cynomolgus monkeys
Dosage: 30 mg/kg/day of vitamin C, orally administered for 40 months

Vitamin C improves brain volume and connectivity, reduces biological age, enhances metabolic health, and alleviates underlying aging drivers, such as cellular senescence, in older monkeys. 

Aging &amp; Longevity

New Data Shows Combining Two Therapies Doubles Lifespan in Mouse Model

Immorta Bio, a biotech company, released results showing that combining its vaccine and stem cell therapy remarkably doubled lifespan in a mouse model of aging.

The biotech company, Immorta Bio, presented data showing a remarkable doubling of lifespan in a mouse model of aging with a combination of its vaccine and stem cell therapy.

Industry

Could Aging Leave a "Memory" That Spreads and Even Passes to the Next Generation?

A new aging model posits that aging imprints signatures across molecular, tissue, and organ system levels, and these signatures may also transmit across generations.

(A new theory posits that imprinted cellular signatures of aging can transmit between generations | NAD.com)

A new theory posits that aging imprints molecular-, cellular-, tissue-, and organ system-level signatures that may transmit across generations.

Model: Young (2- to 4-month-old) and aged (9- to 10-month-old) C57Bl/6JR mice, APP/PS1 mice, and 5xFAD mice 
Dosage: 0.2 mg/mL of doxycycline in drinking water starting at least 7 days before surgery and ceased 2 days before the partial cellular reprogramming window for engram tagging, after which it was immediately reintroduced

Gene Therapy Restores Cognitive Function in Aging and Alzheimer’s Disease

Delivering a gene therapy targeting ensembles of neurons that store memories restores learning and memory capabilities in mouse models of aging and Alzheimer’s disease.

(The study’s principal investigator, Professor Johannes Gräff | 24 Heures)

A partial cellular reprogramming gene therapy targeting memory trace cells restores facets of learning and memory in aged mice and those modeling Alzheimer’s disease.

Brain &amp; Neurons

The Anti-Aging Debate Everyone’s Talking About: Inside Bryan Johnson’s Jubilee Showdown

Bryan Johnson debates 20 skeptics on anti-aging in Jubilee’s viral episode and challenges assumptions about lifespan, science, and the future of human health.


Search Result: iron

Vitamin C Alleviates Aging in Monkeys, New Study Shows

Biotech Company Unveils Data Showing Combining Its Two Therapies Doubles Lifespan in Mouse Model

Could Aging Leave a “Memory” That Spreads and Even Passes to the Next Generation?

Gene Therapy Targeting Memory-Encoding Neurons Restores Cognitive Function in Aging and Alzheimer’s Disease

The Anti-Aging Debate Everyone’s Talking About: Inside Bryan Johnson’s Jubilee Showdown