Aging Clocks Applied to Human Trial Data Support AI-Designed Lung Drug Lowering Age

Six proteomics-based aging clocks (age assessments from large-scale analyses of proteins) agreed that patients treated with the AI-designed drug rentosertib appeared younger.

(A vial containing rentosertib tablets | New York Times)

The AI-designed drug rentosertib was shown to lower biological age across six aging clocks in patients with idiopathic pulmonary fibrosis.

Aging &amp; Longevity

Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

AI may be capable of discovering drugs that target the multitude of biological processes thought to underlie the aging process.  

AI may identify new targets for anti-aging drugs that humans may have overlooked. 

Others

Senolytics: Clearing Troublesome Senescent Cells for Revitalized Aging

Senolytics selectively eliminate senescent cells — non-proliferative cells that release inflammatory molecules to surrounding tissue triggering otherwise healthy cells to enter senescence.

Senolytics, including dasatinib and quercetin along with fisetin, selectively eliminate aged, non-proliferative cells (senescent cells) to revitalize organ health and alleviate age-associated diseases.

Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease 

Researchers in France moderately prolong the lifespan of mice and reverse aspects of skin, bone, lung, and kidney aging with cellular reprogramming — a new technology that rejuvenates cells.  

Corresponding author, Dr. Jean-Marc Lemaitre | franceinfo

Search Result: idiopathic pulmonary fibrosis

Aging Clocks Applied to Human Trial Data Support AI-Designed Lung Drug Lowering Age

Will Interventions that Delay Aging in Animals Work for Humans?

How Scientists Plan to Cure Aging with AI

Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization

French Scientists Show Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease