Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Aging &amp; Longevity

Participants: Werner syndrome patients 
Dosage: 1 gram of NR per day for 26 weeks

The NAD+ (nicotinamide adenine dinucleotide) booster NR (nicotinamide riboside) improves cardiovascular health in Werner syndrome patients. 

A child with Werner syndrome (image: britannica.com)

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

A new human study shows that a procedure involving the replacement of blood plasma with a fresh solution (therapeutic plasma exchange) lowers a measure of how quickly the body is aging (biological age).

(The Buck Institute for Research on Aging | Facebook)

In a first-of-its-kind human trial, participants who underwent therapeutic plasma exchange exhibited significantly lowered biological age.

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Search Result: healthspan

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

NAD+ Precursor NR Improves Heart Health in People with Accelerated Aging, New Study Shows

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

Longevity Prescription

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol