<p><span style="font-weight: 400;">Model: Aged C57B/6 mice (between 18-25 months old) </span></p>
<p><span style="font-weight: 400;">Dosage: 5 mg/kg/day of ABT-263 was fed to mice while 50 mg/kg/day of dichloroacetate and metformin were injected. For lifespan, they were administered for five consecutive days, followed by a two-day intermission, then an additional five consecutive days, followed by a 6-week intermission.</span></p>


The combination of dichloroacetate, metformin, and ABT-263 eliminates cancer cells and age-promoting senescent cells while improving endurance and extending lifespan in mice. 


The study was led by Dr. Irina Conboy (image: berkeley.edu). 

Aging &amp; Longevity

<p><span style="font-weight: 400;">Model: Female Balb/c mice exposed to ultraviolet radiation </span></p>
<p><span style="font-weight: 400;">Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weigh</span><i><span style="font-weight: 400;">t</span></i><span style="font-weight: 400;">/volume) applied topically, once daily, five times per week </span></p>


The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Search Result: chronic stress

Drug Combo Targets Cancer and Senescent Cells to Prolong the Lifespan of Mice, New Study Shows

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Top Evidence-Based Interventions to Lower Biological Age

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain