Model: Male Sprague-Dawley rats 
Dosage: 400 mg/kg of magnesium L-theanine and 600 mg/kg of nicotinamide riboside administered orally for 40 days

Scientists find that treating rats with magnesium L-theanine and nicotinamide riboside (NR) counteracts stress-induced metabolic, gut, and liver aging. 

Study conducted by researchers from Firat University in Turkey (image: turkeyuniversity.org)

Model: UM-HET3 Mice 
Dosage: 0, 75, 150, 300, 600, and 1200 ng epicatechin/mg food; 0, 0.075, 0.15, 0.3, 0.6, and 1.2 ng halofuginone/mg food; and 0, 37.5, 75, 150, 300, and 600 ng mitoglitazone/mg food, all given ad libitum in food starting at seven months old

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

(The three compounds’ effects on median lifespan extension | Rapamycin Longevity News)

The world’s most rigorous longevity study presents data showing promise for three new lifespan-extending compounds in male mice.

Aging &amp; Longevity

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

Model: 39 adults between 18 and 30 years old and 36 adults between 65 and 80 years old
Dosage: ∼595 mg NO3− twice daily from two 70 mL shots of nitrate-rich beetroot juice

Human Trial Finds Nitrate-Enhanced Juice Lowers Blood Pressure

A new human trial yields data showing that nitrate-rich beetroot juice alters the oral microbe composition and lowers blood pressure in older participants.

A new human trial provides evidence that nitrate-rich beetroot juice beneficially modifies the oral microbe composition and lowers blood pressure in older individuals.

Cardiovascular

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.


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New Research: Magnesium, L-Theanine, NAD+ Combo Counters Stress Aging

Three Compounds Show Promise for Male Longevity

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

Human Trial Finds Nitrate-Enhanced Juice Lowers Blood Pressure

Top Aging Expert & Peter Attia Discuss NAD+ Precursors: Taking NMN and NR Together