The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s. 


Principal investigator Michal Shwartz, PhD (Image: Jonathan Bloom).

Brain &amp; Neurons

After accounting for previously unaddressed issues, researchers find that human lifespan is over 50% heritable, challenging previous estimates of 25%.  


Joris Deelen, PhD, one of the researchers on the project (image: stern.de).

Aging &amp; Longevity

The Dementia Surge: New Study Projects Cases to Double by 2060

Researchers project dementia cases in the U.S. to double by 2060, revealing higher incidence in women, Black adults, and APOE ε4 carriers

Considering that, for most of human history, the average human lifespan was 40 years, are we supposed to live beyond this age?

Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Search Result: advancements

Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows

New Study Shows Lifespan is 50% Genetic, Doubling Previous Estimates

The Dementia Surge: New Study Projects Cases to Double by 2060

Are We Supposed to Live Past 40?

Will Interventions that Delay Aging in Animals Work for Humans?