α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.


99-Year-Old Dick Van Dyke’s Secrets to Thriving Longevity

Despite his previous battles with alcoholism, Dick Van Dyke is approaching his 10th decade of life and serves as a beacon for preserving physical function into his golden years.

(At age 99, Dick Van Dyke still maintains a remarkable degree of physical function | NBC News)

At age 99, Dick Van Dyke avoids harmful foods, eats foods high in antioxidants, and keeps moving, a regimen that may have contributed to his astounding longevity.

Aging &amp; Longevity

In a randomized clinical trial, active and healthy older adults who took a multi-supplement and omega-3 fatty acids saw a reduction in age-related chronic inflammation after 12 weeks. 

Search Result: Vitamin D

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Top Aging Expert & Peter Attia Discuss NAD+ Precursors: Taking NMN and NR Together

99-Year-Old Dick Van Dyke’s Secrets to Thriving Longevity

New Clinical Trial: Longevity Stack Fights Age-Related Inflammation