A new scientific review questions how much researchers actually know about fasting’s ability to enhance cellular recycling—particularly in humans.

The spherical structure depicts an autophagolysosome. 

Aging &amp; Longevity

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Participants: Healthy middle-aged to older adults (average age: ~53 years)
Dosage: 1,000 mg/day of urolithin A for 28 days

Supplementing healthy adults with urolithin A —a compound produced by our gut bacteria— counters signs of age-related immune system decline.  

Principal investigator Dr. Florian R. Greten (image: hessen-schafft-wissen.de).

Immunity

The interventions that may help fix or reset circadian rhythms, which decline with age. 

A representation of Kairos, not to be confused with Kronos (original image: misel-trogir.com).

Model: C57BL/6J mice
Dosage: 500 mg/kg/day of Urolithin A in food

Supplementing with urolithin A prevents age-related hearing loss and mitochondrial dysfunction in mice. 

Search Result: Urolithin A

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