Model: Aged C57B/6 mice (between 18-25 months old) 
Dosage: 5 mg/kg/day of ABT-263 was fed to mice while 50 mg/kg/day of dichloroacetate and metformin were injected. For lifespan, they were administered for five consecutive days, followed by a two-day intermission, then an additional five consecutive days, followed by a 6-week intermission.

The combination of dichloroacetate, metformin, and ABT-263 eliminates cancer cells and age-promoting senescent cells while improving endurance and extending lifespan in mice. 


The study was led by Dr. Irina Conboy (image: berkeley.edu). 

Aging &amp; Longevity

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


NAD+ Ranked #2 Most Powerful Anti-Aging Agent

Based on current scientific evidence, Dutch researchers have ranked existing anti-aging interventions based on how likely they are to protect against DNA damage and aging. 


On the far right, one of the researchers, Dr. Jan H.J. Hoeijmakers (image: amazinggerasmusmc.nl). 

DNA Repair

Is Hyperbaric Oxygen Therapy A Rip-off?

Many longevity clinics are popping up across the world, and celebrities are promoting the lifespan-extension fad, sometimes for up to tens of thousands of dollars.

(A woman undergoing hyperbaric oxygen therapy | Northwestern Medicine)

While certain kinds of senescent cells play roles in healing and cancer prevention, many can contribute to aging by promoting inflammation and tissue damage.

When are cells are exposed to certain stressors they become senescent cells and if our immune system can't get rid of them all, some may contribute to aging. 

Search Result: UV Radiation

Drug Combo Targets Cancer and Senescent Cells to Prolong the Lifespan of Mice, New Study Shows

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

NAD+ Ranked #2 Most Powerful Way to Reverse DNA Damage & Aging

Is Hyperbaric Oxygen Therapy A Rip-off?

What Are Senescent Cells and Do They Drive Aging?