Model: Otherwise healthy adults aged 40 and older
Dosage: 15 g of the multi-ingredient supplement dissolved in up to 500 mL of water or juice, given each day orally for six months

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

A six-month human trial found that a multi-ingredient nutritional supplement improved vascular health, reducing arterial stiffness and lowering systolic blood pressure.

(An image depicting increased arterial stiffness [measured with pulse-wave velocity] and blood pressure, along with reduced flow-mediated dilation in aged blood vessels | NAD.com)

A six-month randomized trial found that a multi-ingredient supplement improved vascular health markers, including arterial stiffness and blood pressure.

Cardiovascular

Participants: Older adults at risk for dementia. 
Dosage: 2 g/day of DHA

While it entered the brain, two years of high-dose supplementation revealed no cognitive protection from pure docosahexaenoic acid (DHA) in older adults without dementia.


Brain &amp; Neurons

Model: 20-month-old C57BL/6N male mice (roughly equivalent to 60-year-old humans)
Dosage: 8,000 mg/kg of taurine administered daily via oral gavage for four months

Yale Study Shows How Taurine Reduces Age-Related Inflammation

A new study reveals how taurine helps curb age-related inflammation in aged mice by targeting a key inflammatory pathway in immune cells.

A new study finds that taurine supplementation reduces signs of inflammation and improves some measures of physical function in aged male mice.

Aging &amp; Longevity

Model: Eight-week-old male C57BL/6J mice treated with 400 mg/kg/day of D-galactose via intraperitoneal injection for 12 weeks to induce accelerated aging.
Dosage: 400 mg/kg/day of Antarctic krill oil administered by oral gavage for 12 weeks, alongside D-galactose treatment. A comparison group received 400 mg/kg/day of fish oil under the same conditions.

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

Daily krill oil supplementation preserves muscle strength, endurance, and mitochondrial health in mice with accelerated aging, outperforming fish oil.

Skin &amp; Muscle

Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Search Result: Supplement

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

New USC Study Reveals Popular Omega-3 Supplement Fails to Protect the Brain

Yale Study Shows How Taurine Reduces Age-Related Inflammation

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%