Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

Aging &amp; Longevity

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Dark Chocolate Compound Linked to Slower Aging, Study Finds

Elevated circulating theobromine—derived from cocoa—was associated with a slower pace of aging, according to two assessments.

(The molecular structure of theobromine | Forbes)

A compound derived from dark chocolate, theobromine, circulating at higher levels, is associated with a reduced pace of aging.

Search Result: Supplement

High Protein Intake Promotes Aging by Lowering NAD+ Levels

How to Boost Mitochondrial Density and Quality for Longevity

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Dark Chocolate Compound Linked to Slower Aging, Study Finds