Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

A new human study shows that a procedure involving the replacement of blood plasma with a fresh solution (therapeutic plasma exchange) lowers a measure of how quickly the body is aging (biological age).

(The Buck Institute for Research on Aging | Facebook)

In a first-of-its-kind human trial, participants who underwent therapeutic plasma exchange exhibited significantly lowered biological age.

Aging &amp; Longevity

Amidst transparency issues, neuroscientists can only wonder if Neuralink will face the usual long-term problems of brain-computer interfaces.

Others

Manipulating Aging Through Cutting-Edge Gene Therapies

Gene therapy techniques like CRISPR and RNA replacement compensate for or replace defective longevity-associated genes like KLOTHO or FOXO genes.

(A scientist in a laboratory performing gene therapy research)

Researchers continue to develop ways to substitute, edit, and delete gene sequences to engineer and improve the expression of certain genes related to aging.

Reviews

NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Search Result: RNA Replacement

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

Elon Musk’s Neuralink: What’s Next After First Human Brain Implant?

Manipulating Aging through Cutting-Edge Gene Therapies

NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels