Model: Skin, arterial, and lens tissue from donors between the ages of 20 and 25 and also 75 
Dosage: 5 µM solution of CMLase, incubated overnight

Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

An engineered enzyme reverses age-related protein damage that researchers have long thought irreversible in human eye, skin, and artery tissues.

(A bioengineered enzyme [purple structure] cleaves a prevalent type of AGE [brown glob] on protein residues that are part of protein filaments [dull green chains] | The Scientist)

A bioengineered enzyme reverses age-related protein damage, long thought of as irreversible damage, in human lens, skin, and artery tissues.

Basic Research

Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging

The Chinese Academy of Sciences' findings may explain why aging makes us sicker and suggest new ways to detect and reverse aging.

(Chinese Academy of Sciences | Ferdowsi University of Mashhad)

Aging &amp; Longevity

Model: hESC-derived neurons
Dosage: Nicotinamide (NAM) (Sigma-Aldrich), 1 mM Nicotinamide riboside (NR) (ChromaDex), 1 mM Nicotinamide mononucleotide (NMN) (NMN Bio)

 Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases

A new study from MIT and the University of Birmingham in the UK shows that the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can save neurons with dysfunctional cell recycling (autophagy) that looks like neurodegenerative and lysosomal storage diseases.


Scientists Identify Hallmarks of Aging that Can Be Reversed 

Twelve underlying drivers of aging can potentially be slowed, prevented, or reversed to improve health and extend lifespan. 

Investigators Dr. Guido Kroemer (left) and Dr. Carlos Lopez-Otin (right) | El Comercio 

Reviews

Stress From Natural Disasters Accelerates Biological Aging

New data shows that exposure to Hurricane Maria accelerated aging in rhesus macaques monkeys and altered immune cell composition.  


Study finds Hurricane Maria accelerated biological aging in rhesus macaques, highlighting stress' impact on gene activity linked to aging and immune function.

Search Result: Proteostasis

New Research: Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

Researchers Identify Key Cellular Changes Around Age 50 That Accelerate Aging

Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases

The Hallmarks of Aging and How To Target Them

Scientists Use Natural Disasters to Prove that Stress Accelerates Biological Aging