Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Aging &amp; Longevity

Transplanting age-driving senescent cells in the skin triggers muscle aging, bone aging, and cognitive decline in mice.  

Brain &amp; Neurons

Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Model: Humans between the ages of 21 and 72
Dosage: Oral dosage of 500 mg of nicotinamide, 600 mg of alpha lipoic acid, 10 mg of zinc, 20 mg of vitamin C, and 2,110 mg of a botanical blend containing green tea extract, rutin, parsley leaf extract, and black pepper fruit daily for 28 days

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

British researchers designed a nutraceutical to maximize nicotinamide adenine dinucleotide (NAD+) levels that significantly lowers biological age.

British researchers used a nutraceutical targeting multiple NAD+ biosynthesis- and breakdown-related enzymes to increase NAD+, lower inflammation, and increase sirtuins.

The large-scale preclinical study shows that SRN-901 significantly extends lifespan and healthspan while improving a great number of aging parameters.


Seragon Biosciences increases the lifespan and healthspan of mice in one of the largest studies of its kind. 

Search Result: Nutraceutical

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

New Mayo Clinic Research Links Skin Aging to Cognitive Decline

Will Interventions that Delay Aging in Animals Work for Humans?

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date