Participants: Healthy male adults between the ages of 18 and 50 
Dosage: 714 mg/day of nicotinamide and 19 mg/day of pyridoxine for nine days

In a randomized human trial, combining nicotinamide with vitamin B6 increases stem cell activation and muscle-growth capacity in response to exercise. 

Skin &amp; Muscle

<ul>
<li style="font-weight: 400;" aria-level="1">The monkeys used in the study, including eight young ones (4–6 years old, four females and four males) and eight aged ones (18–21 years old, four females and four males), were originally from Southeast Asia.</li>
<li style="font-weight: 400;" aria-level="1">Three groups of male C57BL6/J mice: young-lenti-Luc (2-month-old), aged-lenti-Luc (24-month-old) and aged-lenti-SIRT2 (24-month-old).</li>
<li style="font-weight: 400;" aria-level="1">hiPSC derived CMs</li>
</ul>

New Study Reveals Activating Sirtuins Could Reverse Heart Aging 

Researchers have identified a sirtuin (SIRT2) as a therapeutic target for age-related cardiovascular disease.

Cardiovascular

Model: hESC-derived neurons
Dosage: Nicotinamide (NAM) (Sigma-Aldrich), 1 mM Nicotinamide riboside (NR) (ChromaDex), 1 mM Nicotinamide mononucleotide (NMN) (NMN Bio)

 Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases

A new study from MIT and the University of Birmingham in the UK shows that the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can save neurons with dysfunctional cell recycling (autophagy) that looks like neurodegenerative and lysosomal storage diseases.


Model: Male rats
Dosage: Doxorubicin (DOX) for 12 days (2 mg/kg/day)

Heart Health Improved by Gold Particles That Boost NAD+, Study Shows  

Apigenin-coated gold particles protect rat hearts from damage by blocking cell death.

 Apigenin-coated gold nanoparticles reduce doxorubicin-induced heart damage, offering a new cardioprotective strategy in cancer therapy.

German scientists find that genetic reprogramming — a rising technology that reverts cells to an earlier stage of development — improves heart regeneration after heart attack in mice. 


Max Planck Institute for Heart and Lung Research

Search Result: Myocytes

NAD+ Booster and Vitamin B6 Activate Stem Cells to Counter Muscle Shrinkage, New Studies Show

New Study Reveals Activating Sirtuins Could Reverse Heart Aging

Latest MIT Study Shows NMN and NR Are Potential Targets for Neurodegenerative Diseases

Heart Health Improved by Gold Particles That Boost NAD⁺, Study Shows

Age-Reversing Technology Promotes Heart Repair After Heart Attack: German Study