Model: Otherwise healthy adults aged 40 and older
Dosage: 15 g of the multi-ingredient supplement dissolved in up to 500 mL of water or juice, given each day orally for six months

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

A six-month human trial found that a multi-ingredient nutritional supplement improved vascular health, reducing arterial stiffness and lowering systolic blood pressure.

(An image depicting increased arterial stiffness [measured with pulse-wave velocity] and blood pressure, along with reduced flow-mediated dilation in aged blood vessels | NAD.com)

A six-month randomized trial found that a multi-ingredient supplement improved vascular health markers, including arterial stiffness and blood pressure.

Cardiovascular

Model: 20-month-old C57BL/6N male mice (roughly equivalent to 60-year-old humans)
Dosage: 8,000 mg/kg of taurine administered daily via oral gavage for four months

Yale Study Shows How Taurine Reduces Age-Related Inflammation

A new study reveals how taurine helps curb age-related inflammation in aged mice by targeting a key inflammatory pathway in immune cells.

A new study finds that taurine supplementation reduces signs of inflammation and improves some measures of physical function in aged male mice.

Aging &amp; Longevity

A new U.S. Army study shows that waist circumference and belly fat are far stronger determinants of circulating testosterone levels than aging.


An image from a previous publication authored by Dr. Karl E. Friedl, one of the U.S. Army scientists on the current study. 

Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Protein Restriction and Longevity: Can Limiting Protein Intake Support Healthy Aging?

University of Wisconsin researchers examine how reducing dietary protein intake may reshape nutrient sensing, metabolism, mitochondrial function, and other pathways linked to healthier aging.

(One of the leading authors on the Cell Press Blue article, Dr. Dudley Lamming | University of Wisconsin)

Researchers examine how restricting protein intake can improve metabolic health and influence aging-related pathways to extend healthspan and lifespan.

Search Result: Metabolic Disease

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

Yale Study Shows How Taurine Reduces Age-Related Inflammation

Why Low Testosterone Isn’t Just About Getting Older: New U.S. Army Findings Point to Belly Fat

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Protein Restriction and Longevity: Can Limiting Protein Intake Support Healthy Aging?