Unpublished Results Show NMNH Triples NAD+ in First Human Trial

According to newly released results from a first-of-its-kind clinical trial, reduced nicotinamide mononucleotide (NMNH) triples circulating NAD+ and improves subjective quality of life scores.

(An image of NMN and reduced NMN [known as NMNH] with an additional hydrogen atom | Effepharm)

Results from a first-of-its-kind human trial show that reduced nicotinamide mononucleotide (NMNH) triples circulating NAD+ levels.

Clinical Trials

Model: Male C57BL/6J mice 
Dosage: 150 mg/kg/day of diallyl sulforated compounds in food

Diallyl sulfonated compounds (DAS), found in garlic, extend the lifespan of mice while counteracting signs of aging, such as grip weakness and memory loss. 

Dr. Vivian Capilla-González, one of the researchers on the study (image: cde.ual.es).

Aging &amp; Longevity

Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

Search Result: Longevity

Unpublished Results Show NMNH Triples NAD+ in First Human Trial

Garlic Compound Extends Life, Builds Strength, and Boosts Memory, New Study Shows

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing COX7RP Improves Energy Production and Extends Lifespan

How to Boost Mitochondrial Density and Quality for Longevity