Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Participants: Prefrail older adults
Dosage: 50 mg/day of losartan for at least 8 weeks

Losartan, a common blood pressure medication, increases the survival rate of mice and improves the metabolic outlook of pre-frail older adults. 

Principal Investigator of the study, Dr. Peter M. Abadir (image: jhu.edu).

What Is Mosaic Aging? How Organs Age at Different Rates

A new framework proposes that the patchwork nature of aging, where different organs deteriorate at different speeds, may hold the key to understanding the ultimate cause of death.

(University of Glasgow logo | Scotland.org)

A new framework proposes that aging occurs unevenly in cells, tissues, and organs, and that targeting the fastest-aging tissues may extend lifespan.

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Search Result: Kidney disease

Top Evidence-Based Interventions to Lower Biological Age

New Johns Hopkins Study: FDA-Approved Losartan May Extend Lifespan

What Is Mosaic Aging? How Organs Age at Different Rates

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions