Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

A new human study shows that a procedure involving the replacement of blood plasma with a fresh solution (therapeutic plasma exchange) lowers a measure of how quickly the body is aging (biological age).

(The Buck Institute for Research on Aging | Facebook)

In a first-of-its-kind human trial, participants who underwent therapeutic plasma exchange exhibited significantly lowered biological age.

Aging &amp; Longevity

"Steroids Are Awesome" - But Here’s How They Accelerate Aging

Natural bodybuilder Jeff Nippard exposes the real truth about anabolic steroids, highlighting the benefits and risks while urging transparency in the fitness community. 

Jeff Nippard exposes the real truth about anabolic steroids, highlighting the benefits and risks while urging transparency in the fitness community. 

Skin &amp; Muscle

Shawn Baker, M.D., says self-proclaimed longevity experts are nothing but grifting modern-day snake oil salesmen.


Dr. Shawn Baker (image: Pederson Farms Podcast)

Shawn Baker, M.D., says to beware of anyone promising life extension in exchange for money. 

Based primarily on discussions with guests on his popular podcast, the supplements Joe Rogan has taken include NMN, resveratrol, vitamin D, fish oil, and more.  



Joe Rogan (Image: Joe Rogan’s X account) 

The supplements that Joe Rogan has taken, according various social media posts and conversations he's had with guest on his podcast. 

Search Result: Gene Replacement

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

“Steroids Are Awesome” – But Here’s How They Accelerate Aging, Heart Disease, and Brain Decline, According to Jeff Nippard

Candid Doctor Calls Out “Longevity Experts” Like Peter Attia and David Sinclair

Podcaster Joe Rogan’s Top 2024 Supplements Beyond NAD+ Precursor NMN