NAD+ (nicotinamide adenine dinucleotide) may contribute to healthy cellular aging by enhancing biological energy flow, according to the newly formulated energy resistance principle.


Aging &amp; Longevity

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Model: Naturally aged C57BL/6J mice

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

A new study provides data suggesting compromised intestinal function with age and that fasting for short periods promotes intestinal regeneration and function in aged mice.

(A dysfunctional intestinal barrier that leaks harmful substances and bacteria into circulation develops with age | The Amino Company)

Alternate-day fasting, a form of intermittent fasting, reverses age-related intestinal barrier leakage in old mice.

Model: Male Wistar rats (4-month-old young rats and 24-month-old old rats)
Dosage: Oral administration of the trypsin inhibitor tranexamic acid in drinking water for 14 days at a minimum dose of 0.39 g/kg/day after consuming about 40 mL/day of water

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

University of California, San Diego researchers show digestive enzyme leakage from the intestines contributes to organ damage in old rats, offering what may be a new way to explain aging.

(Principal investigator, Geert Schmid-Schönbein | voiceofsandiego.org)

How to counteract age-related gut microbe alterations through diet, lifestyle interventions, and supplements. 

Counteracting the aging microbiome with a fiber-rich diet and supplements. 

Search Result: Digestion

Boosting NAD+ May Defy Aging by Enhancing Energy Flow, According to a New Theory

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

How to Improve Gut Microbiome Health with Age