Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Model: 14- to 15-month-old male C57BL/6J mice
Dosage: 50 mg injection of 3′-deoxyadenosine (cordycepin) because it was shown not to be absorbed if administered orally

Mushroom Compound Prolongs Lifespan If Taken At Correct Time

In mice, cordycepin—a molecule found in cordyceps mushrooms—prolongs lifespan and improves memory, strength, cardiac function, hormone levels, and metabolism. 


Cordyceps mushrooms (image: antioxi-supplements.com). 

Aging &amp; Longevity

Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Search Result: Cholesterol

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

Rapamycin and Exercise: New Study Finds Potential Performance Decline

Cordyceps Mushroom Molecule Prolongs Lifespan If Taken At Correct Time of Day, New Study Shows

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan