Model: Male Wistar rats 
Dosage: 1.5 g/kg/day of orally administered glycine for 5 months

Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

Aging &amp; Longevity

Model: Six adults who received intravenous NAD+ and eight adults who received intravenous NR
Dosage: 500 mg of intravenous NAD+ or 500 mg of intravenous NR daily for four consecutive days

Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

A Stanford study supports the short-term safety of NAD+ and NR infusion therapies, and participants who received NR infusions exhibited significantly lower HbA1c (a blood test that reflects average blood sugar over two to three months).

(An IV bag containing a solution with NAD+ | Crete Fertility Centre)

A Stanford human trial provides the first data supporting the safety of NAD+ IV and NR IV therapies.

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Search Result: Cholesterol

Glycine Extends Life & Counters Brain and & Muscle Degeneration, New Study Shows

Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

Top Evidence-Based Interventions to Lower Biological Age

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

Rapamycin and Exercise: New Study Finds Potential Performance Decline