Participants: Healthy males (age range: 70-76)
Dosage: 1 mg/kg/day of rapamycin for 8 weeks

Supplementing with rapamycin leads to improvements in cardiac and vascular function in older men, suggesting this longevity-associated drug may counteract cardiovascular aging. 

Nicolas Musi, MD, professor of medicine and an author of the study (image: sanantoniomag.com). 

Cardiovascular

Model: Aged mice (18 months old) underwent exploratory laparotomy under isoflurane anesthesia to induce POCD.
Dosage: Berberine was given by oral gavage at 100 mg/kg per day for 14 days after surgery.

Ancient Plant Compound Shows Promise for Protecting the Aging Brain 

Study shows berberine, a natural plant compound, protects memory in aging mice after surgery by reducing brain inflammation, stress, and cell damage.


Brain &amp; Neurons

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques. 

A young crab-eating macaque (image: shutterstock.com). 

Aging &amp; Longevity

Does NAD+ (nicotinamide adenine dinucleotide) really help with aging? A team of international scientists reviews the latest and ongoing clinical trials.

Part of the research team, including Dr. Evandro Fei Fang (middle), from the University of Oslo and Akershus University Hospital in Norway (image: med.uio.no). 

Search Result: Brain

Longevity Drug Rapamycin Improves the Heart of Older Adults, New Study Shows

Ancient Plant Compound Shows Promise for Protecting the Aging Brain

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

Anti-Aging Breakthrough: Stem Cells Reverse Signs of Aging in Monkeys

NAD+ and Aging: What the Latest Research Says