Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Aging &amp; Longevity

Participants: Healthy adults 
Dosage: An escalating dose of niacin (250-1000 mg/day) for 16 weeks

Finnish scientists used a new measurement system to detect low NAD+ levels in blood samples from people with a range of age-related conditions, but not in healthy older individuals.


Principal Investigator of the study, Dr. Anu Suomalainen (image: helenski.fi).

Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Researchers at Case Western Reserve University have shown that late-stage neurodegeneration may be biologically reversible, at least in the right conditions, in mice.

(Case Western Reserve University | Cleveland 19)

Brain &amp; Neurons

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Search Result: Alzheimer

Rapamycin and Exercise: New Study Finds Potential Performance Decline

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

NAD+ Levels in Healthy Aging: New Study Reveals Surprising Trends

Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age