Model: Young acquired niacin dependency (ANDY) mice. 
Dosage: 30 mg/kg/day of niacin

Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

NAD+ is not the same as vitamin B3. However, NAD+ is considered the bioactive form of vitamin B3 because vitamin B3 is converted to NAD+ in the body. 


The main purpose of vitamin B3 is to maintain NAD+ levels. 

Search Result: pellagra

NAD+ Depletion Shortens Lifespan in Mice—but Restoring NAD+ Reverses Health Decline: New Mayo Clinic Study

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Is NAD+ the Same as Vitamin B3?