Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Model: Humans between the ages of 21 and 72
Dosage: Oral dosage of 500 mg of nicotinamide, 600 mg of alpha lipoic acid, 10 mg of zinc, 20 mg of vitamin C, and 2,110 mg of a botanical blend containing green tea extract, rutin, parsley leaf extract, and black pepper fruit daily for 28 days

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

British researchers designed a nutraceutical to maximize nicotinamide adenine dinucleotide (NAD+) levels that significantly lowers biological age.

British researchers used a nutraceutical targeting multiple NAD+ biosynthesis- and breakdown-related enzymes to increase NAD+, lower inflammation, and increase sirtuins.

While certain kinds of senescent cells play roles in healing and cancer prevention, many can contribute to aging by promoting inflammation and tissue damage.

When are cells are exposed to certain stressors they become senescent cells and if our immune system can't get rid of them all, some may contribute to aging. 

Aging &amp; Longevity

Model: C57BL/6J mice
Dosage: 300 mg/kg intraperitoneal injection at 22 months of age

Washington University Study: NMN Restores NAD+ in an Age-Modulating Brain Region

NMN replenishes faltering NAD+ levels in a brain region called the hypothalamus, a region that may control aging-associated processes.

(The study’s principal investigator, Shin Ichiro-Imai, MD, PhD | mspremium.com)

NAD+ levels falter in a brain region that controls sleep, appetite, thirst, and parental behavior, but NMN and/or vesicles containing the NMN-synthesizing enzyme NAMPT replenish NAD+.

Model: C57Bl6 young and aged mice
Dosage: 25 mg/kg/day CASIN via IP injection; 4 day treatment

Rejuvenated Stem Cells Prolong Lifespan and Increase Muscle Fitness

Spanish scientists find that drug-induced stem cell rejuvenation improves muscle strength and size while significantly increasing the lifespan of mice.


Senior author, Dr. M. Carolina Florian | Bellvitge Biomedical Research Institute

Spanish scientists find that drug-induced stem cell rejuvenation improves muscle strength and size while significantly increasing the lifespan of mice.

Search Result: npj Aging

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

What Are Senescent Cells and Do They Drive Aging?

Washington University Study: NMN Restores NAD⁺ in an Age-Modulating Brain Region

New Study Shows Rejuvenated Stem Cells Prolong Lifespan and Increase Muscle Fitness