Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Brain &amp; Neurons

Participants: Healthy overweight adults between the ages of 45 and 55 
Dosage: 3 grams/day of ginseng for 28 days

Ginseng Boosts NAD+ and Telomeres: New Study in Middle-Aged Adults

Ginseng supplementation boosts NAD+ (nicotinamide adenine dinucleotide) and lengthens telomeres in middle-aged adults, suggesting an amelioration of aging. 


Panax ginseng Meyer (image: farmaimpresa.com).

Aging &amp; Longevity

Model: Male C57BL/6 mice injected with D-galactose to accelerate aging 
Dose: 100 mg/kg aminoguanidine or 40 mg/kg resveratrol injections

Resveratrol — a naturally occurring anti-aging compound — preserves kidney structure, prevents dysfunction, and quenches harmful senescent cells in age-accelerated mice. 

Abstract depiction of scientist holding a microscope slide with kidney sample (generated by Midjourney).

Others

Model: C57BL/6J mice
Dosage: alpha lipoic acid (20.19%), nicotinamide (57.68%), thiamine hydrochloride (4.04%), piperine (1.73%), and pyridoxamine dihydrochloride (16.36%) incorporated into modified mouse chow

Lifespan Prolonged, Blood Glucose Lowered, and Body Fat Reduced with Combo Therapy

A combination of B vitamins (B1, B3, and B6), alpha lipoic acid, and piperine significantly increases the lifespan of aged mice, lowers blood glucose, and reduces body fat. 


Senior Author, Dr. Pankaj Kapahi | Eric Luse, The Daily 

Search Result: glycation

Common Joint Health Supplement May Progress Dementia, New Study Finds

Ginseng Boosts NAD+ and Telomeres: New Study in Middle-Aged Adults

Taiwanese Study Reveals Resveratrol’s Remarkable Role in Kidney Health and Senescent Cell Reduction

Buck Scientists Increase Lifespan, Lower Blood Glucose, and Reduce Body Fat with Combo Therapy