Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Brain &amp; Neurons

Aging Guru Bryan Johnson’s Supplement List for 2026

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

(Bryan Johnson, who utilizes a continuously updated protocol to slow aging and optimize his body | Netflix)

Changes to Bryan Johnson’s updated 2026 supplement stack include taking NMN or NR six days a week instead of seven and removing rapamycin.

Aging &amp; Longevity

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Based primarily on discussions with guests on his popular podcast, the supplements Joe Rogan has taken include NMN, resveratrol, vitamin D, fish oil, and more.  



Joe Rogan (Image: Joe Rogan’s X account) 

The supplements that Joe Rogan has taken, according various social media posts and conversations he's had with guest on his podcast. 

45-year-old Bryan Johnson, the walking longevity experiment (n = 1), takes over 100 pills a day, adheres to a primarily vegan diet, and more to reverse his biological age. 


Bryan Johnson wearing what appears to be a Kernel brain-computer interface helmet. | Blueprint

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