University of Southern California (USC) scientists help to uncover why human intelligence declines with age, pointing to a newly discovered cellular target.


The principal investigator on the study, Dr. Michael Bonaguidi (image: usc.edu).

Brain &amp; Neurons

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Model: C57BL/6 mouse
Treatment: ROCKi

Stanford Researchers Reactivate Brain Stem Cells in Old Mice

These results demonstrate an approach for increasing the neuron-producing potential of old brain stem cells and have implications for restoring neurogenesis in the aged brain.


Dr. Robin Yeo, Ph.D. | Study's Lead Author 

Explore the groundbreaking study by Stanford researchers, unveiling the reactivation of brain stem cells in older mice. Discover the exciting findings and implications of this research at NAD.com.

Stanford Researchers Successfully Reactivate Brain Stem Cells in Aging Mice | NAD

Removing Senescent Immune Cells Prevents Cognitive Decline: Mayo Clinic

A Mayo Clinic study shows that clearing senescent (aged) immune cells from the brains of mice helps prevent executive functioning deterioration and memory loss.

Co-author, Dr. E. Aubrey Thompson | Play for P.I.N.K. 

B6 congenic 5XFAD 4-month-old mice
Wildtype B6 mice
100 µL F. nucleatum
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Gum Disease May Increase Alzheimer’s Risk

Researchers show that the oral pathogen Fusobacterium nucleatum (F. nucleatum) decreases cognitive function and exacerbates Alzheimer's features in mice modeling Alzheimer's. 

Oral bacteria F. nucleatum may escalate Alzheimer's progression, linking gum disease to increased cognitive decline, brain inflammation, and Alzheimer's markers.

Search Result: glial cells

Beyond Neurons: New Study Pinpoints Immature Brain Cells Behind Age-Related Drops in Intelligence

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

Stanford Researchers Reactivate Brain Stem Cells in Old Mice

Mayo Clinic Researchers Show Removing Senescent Immune Cells Prevents Cognitive Decline

Gum Disease Pathogen Fusobacterium nucleatum May Increase Alzheimer’s Risk