Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Aging &amp; Longevity

<p>Model: Healthy adults between 21 and 79 years of age<br />
Dosage: 395 mg/kg of bodyweight of (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate monoester (𝛽-hydroxybutyrate ketones) diluted in water and administered once</p>


New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

A new study suggests that supplementing with ketones—molecules the body can use for energy when lacking sugars—prevents cognitive aging when administered in people’s 40s and 50s.

(The study’s principal investigator, Dr. Lilianne R. Mujica-Parodi | Stony Brook University News)

Based on age-related destabilized brain signaling, a new study suggests a critical midlife window where metabolic interventions may stabilize brain signaling.

Brain &amp; Neurons

The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s. 


Principal investigator Michal Shwartz, PhD (Image: Jonathan Bloom).

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.  


Principal investigator Nora Kory, PhD, from Harvard University (image: harvard.edu). 

Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

Search Result: cognitive decline

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows

Harvard Scientists Unravel the Role of NAD+ Transporter in Mitigating Age-Related Diabetes

Jumpstarting the Brain Reduces Alzheimer’s Progression by 52% in New Phase II Trial.