Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

Brain &amp; Neurons

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Supplementing with ergothioneine — a compound found in lion’s mane mushrooms — enhances the verbal memory of elderly individuals. 

(Image: marthastewart.com) Lion’s mane mushrooms.

Stanford Researchers Propose Psychological Stress as a Critical Hallmark of Aging

Stanford scientists propose that the impact of psychological elements like trauma and depression are key drivers of aging.

Stanford researchers propose designating psychological factors like past trauma, depression, and loneliness as a new hallmark of aging.

Search Result: Trauma

Top Evidence-Based Interventions to Lower Biological Age

Accessing Technology that Reduces Alzheimer’s Memory Loss by 52%

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Ergothioneine Longevity Supplement Enhances Verbal Memory

Stanford Researchers Propose Psychological Stress as a Critical Hallmark of Aging